Transformation of proliferative verrucous leukoplakia to. However, leukoplakia is not limited as an oral disorder alone, as it may also appear in the genital area of the female. Transformation of proliferative verrucous leukoplakia to oral carcinoma. Leukoplakia are thick, whitishcolor patches that form on the inside of the cheeks, gums or tongue, these patches are caused by excess cell growth and are common among tobacco users. Leukoplakia is typically not hazardous, but it often can be serious. It is proliferative verrucous leukoplakia of the gingiva. The primary outcomes of interest were clinical resolution, malignant transformation, followup, and recurrence of ol. Therefore, it is advised to see the dentist if an individual has persistent, unusual changes in the mouth. You can also get them on the inside of your cheeks. Users can purchase an ebook on diskette or cd, but the most popular method of getting an ebook is to purchase a downloadable file of the ebook or other reading material from a web site such as barnes and noble to be read from the users computer or reading device. Nine files of patients with pvl, diagnosed between 2007 and 2011 and 29. It develops in the mouth, genital, and in some cases, it is formed in the internal.
After this study, these lesions were named oral proliferative verrucous leukoplakia opvl. Case report of rapidly progressive proliferative verrucous. Medicina bucal jose v bagan sebastianfull description. Oral leukoplakia tsvetanov ts1 abstract oral leukoplakia is defined as a predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion.
Leukoplakia is a condition wherein white or gray patches appear in some parts of the mouth, predominantly in the buccal mucosa and the tongue. A white patch in your mouth that does not go away should be checked by a dentist or gp. Leukoplakia is a relatively common clinical finding in clinical medicine. Leukoplakia first appears as a small, smooth, white spot that cannot be scraped off but develops into a. Symptoms and treatment of cervical leukoplakia, oncology. Jscholar publishers proliferative verrucous leukoplakia of the gingiva, report of two cases with malignant transformation nadereh ghanee dmd, selene saraf, mary nathanson kilo md and kristina waggoner pacific northwest kaiser dental, usa. Leukoplakia causes, pictures, symptoms, treatment, prognosis. A leucoplasia verrucosa proliferativa lvp e classificada como um subtipo da. Head and neck cancer, including oral cancer, is also discussed separately. The word leukoplakia means white patch, and is derived from the greek words. Proliferative verrucous leukoplakia pvl is an uncommon form of progressive multifocal leukoplakia with a high rate of malignant transformation to either squamous cell cancer or verrucous carcinoma and a high probability of recurrence. This report is of a 59yearold female who presented to the periodontal department with linear gingival leukoplakia. It starts as a white plaque of thickened skin hyperkeratosis that eventually spreads and forms rough, wartlike verrucous lesions that may look. Proliferative verrucous leukoplakia clinical presentation.
Among them oral leukoplakia ol is quite prevalent 0. Proliferative verrucous leukoplakia of the gingiva, report. Medicina bucal jose v bagan sebastian pdf free download. However, this report described a case of rapid progress, which had malignant. Leukoplakia, precancerous tumour of the mucous membranes, usually seen in the mouth or on the tongue or cheeks, but also known to occur on the lips, as well as on the vagina, vulva, or anus. Pdf the proliferative verrucous leukoplakia pvl is a white plate, wartlike, exophytic, slow growth, which does not follow the scaling that tends. Not all white patches are called leukoplakia just the ones that cannot be rubbed off and cannot be diagnosed as any other condition or disease figures 14.
Leucoplasia verrugosa proliferativa revistas universidad catolica. Since then, various published case series have presented pvl as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. Leukoplakia and erythroplakia sean parker institute for. Banoczy 5 showed that 26 percent of carcinomas developed in speckled leukoplakia, whilst only 2 percent carcinomas developed from theothertype ofleukoplakia.
Pdf the authors present a case of proliferative verrucous leukoplakia pvl in a 78yearold man. Most patches of leukoplakia are benign, but a small number can show early cancer symptoms, and numerous mouth cancers develop beside the areas of leukoplakia. Proliferative verrucous leukoplakia genetic and rare. The most effective methods of oral leukoplakia treatment.
In this study the prevalence of leukoplakia in a selected population was 2. Proliferative verrucous leukoplakia pvl is a rare oral leukoplakia and has four features such as chronic proliferation, multiple occurrences, refractoriness to treatment and high rate of malignant transformation. This function is accomplished through a ligation between betacarotene and oxygen, which is an unstable reactive molecule, thus diminishing the damaging effects of free radicals lycopene in vitro experiments have shown the inhibition of the process of human neoplastic cellular growth by lycopene, since this. Proliferative verrucous leukoplakia, analysis of biomarkers present in. The proliferative verrucous leukoplakia pvl is a white plate, wartlike, exophytic, slow growth, which does not follow the scaling that tends to compromise various oral mucosal sites. Carcinoma, proliferative verrucous leukoplakia and ebv epsteinbarr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma. Leukoplakia genetic and rare diseases information center.
Leucoplasia verrucosa proliferativa lvp e uma lesao multifocal e progressiva da mucosa oral, com etiologia desconhecida e comumente. This leukoplakia was broad in its distribution and of unknown duration or aetiology. This article looks at leukoplakia of the head and neck hairy leukoplakia is dealt with separately. Oral leukoplakia, oral toxicities associated with chemotherapy, gingivitis, periodontal disease, odontogenic infections, and halitosis are discussed separately. Leukoplakia could be classified as mucosal disease, and also as a premalignant condition. When affecting the vocal folds, they will generally cause changes that can range from simple hoarseness to complete loss of voice. Leukoplakia etiology, prevalence, clinical features. Ol is premalignant and is associated with squamous cell carcinoma scc. Summary proliferative verrucous leukoplakia pvl is an aggressive and distinctive form of. Proliferative verrucous leukoplakia of the gingiva how. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations. Proliferative verrucous leukoplakia of the gingiva listed as pvlg. Any transmission of this document by any media or format is strictly.
An aggressive form of oral leukoplakia thomas p shopper, robert b brannon and william h stalker thomas p. Oral leukoplakia is a potentially malignant disorder affecting the oral mucosa. Pdf leucoplasia verrucosa proliferativa estudo sobre os. Analisi retrospettiva di 12 casi proliferative verrucous leukoplakia. Leukoplakia and erythroplakia can go unnoticed when they occur in the mouth or the throat, and are sometimes found during a routine head and neck examination, or voice screening. Clipping is a handy way to collect important slides you want to go back to later. Proliferative verrucous leukoplakia is a rare and distinct variant of oral leukoplakia. Soames and southam reported mutations of p53 in the cells from dysplastic areas of some leukoplakias who smoke and drink heavily. Microscopically, it may show hyperplasia, dysplasia or. It mainly involves the lining inside of the cheeks buccal mucosa and tongue. Pdf 58 medicina oral leucoplasia verrucosa proliferativa. Proliferative verrucous leukoplakia x oral leukoplakia. The management of oral leukoplakia varies from a wait and see attitude and topical chemopreventive agents to complete surgical removal. Volume 79, issue 5, may 2011, pages 242244, 247248, 251, 252253.
Leukoplakia, management, surgical, nonsurgical treatment, introduction oral leukoplakia ol is the most frequent precancerous lesion of the oral cavity. Leucoplasia verrucosa proliferativa x leucoplasias oral. K institute of dental sciences, belgaum, karnataka, india 3 department of oral medicine and radiology, k. Leukoplakia can develop erosion of the seal and is on the cervix as a white spot. Clinical and histopathological description of oral leukoplakia.
Proliferative verrucous leukoplakia pvl lesions commonly occur on the buccal mucosa, gingiva, tongue, floor of the mouth, and palate. Leucoplasia verrucosa proliferativa, leucoplasia oral, patologia oral. The main purpose of oral leukoplakia management is to avoid malignant transformation of the lesion or if this happened to detect this in early stages. They can result from irritations such as an illfitting denture or the habit of chewing on the inside of the cheek. A case report with an update rakhi issrani 1, namdeo prabhu 2, vaishali keluskar 3 1 department of oral medicine and radiology, saraswati dental college, lucknow, uttar pradesh, india 2 department of oral and maxillofacial surgery, k. The condition is thought to be caused by irritation, but the cause is not always known. White lesions both physiologic as well as pathologic are relatively frequent in the oral cavity, the most common pathology being oral leukoplakia ol. Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Leukoplakia are patches on the tongue, in the mouth, or on the inside of the cheek.
Examination early in the disease process may reveal isolated areas of leukokeratosis, sometimes with adjacent erythematous mucosa, as. Proliferative verrucous leukoplakia of the gingiva how is proliferative verrucous leukoplakia of the gingiva abbreviated. Leukoplakia is a white lesion and the most common oral potentially malignant disorder occurring in the oral cavity. There are many variants of ol and proliferative verrucous leukoplakia pvl is one of the least frequent. Leukoplakia luke o plake ee ah is a clinical term that is used to describe certain white patches in the mouth. Proliferative verrucous leukoplakia is a multifocal. As mentioned above, most pvl cases processed to malignancy over many years, sometimes 20 years. Although the sores can vary in appearance, they are usually white or gray. Retinoids and proliferative verrucous leukoplakia pvl. Shopper, dds, med, is an associate pr ofessor in the department of or al diagnosis, oral medicine, and radiology. Proliferative verrucous leukoplakia pvl is a rare form of oral leukoplakia, which was first described in 1985 by hansen et al. Proliferative verrucous leukoplakia pvl is a rare type of oral leukoplakia, where white patches that have a high risk of becoming cancerous develop inside the mouth. Lara cristina oliver gimenez leucoplasia verrucosa. The proliferative verrucous leukoplakia pvl is a white.
It is defined as essentially an oral mucosal white lesion that cannot be considered as any other definable lesion. Now customize the name of a clipboard to store your clips. Leukoplakia affects the mucous membranes of the mouth. Although the white color in leukoplakia is a result of hyperkeratosis or acanthosis, similarly appearing white lesions that are caused by reactive keratosis smokers keratosis or frictional keratoses e. Carcinoma, proliferative verrucous leukoplakia and ebv med oral patol oral cir bucal. The authors concluded that no significant difference in the occurrence of hpv infection existed between the two conditions. This result should be interpreted with great caution since the relatively small size and highly selected character of the screened population was investigated. Leucoplasia verrucosa proliferativa anatomia patologica.